This high incidence of malignancy reported in our study is similar to that of Tai et al. It was contributary in 35 out of 61 cases Thyroid nodules that should be considered for FNA include any firm, palpable, solitary nodule or nodule associated with worrisome clinical features rapid growth, attachment to adjacent tissues, hoarseness, or palpable lymphadenopathy. Clinical examination including determination of presence or absence of toxic manifestations and enlarged cervical lymph nodes was done. Also it classifies the nodules into solid, cystic, or mixed. If the report was benign, the patient was managed by regular monitoring of hormone levels, with or without thyroid hormone supplementation.
Ultrasonography is the most cost-effective imaging procedure, and is highly sensitive in assessing nodule size and number. Lymph nodal enlargement was detected by USG in 28 patients. Cell biology and flow cytometry.
Histopathological examination showed two of these cases were nodular goiter, eight were follicular adenoma, three were follicular carcinoma, four were follicular variant of papillary carcinoma and one case was parathyroid carcinoma. Other less common symptoms thyrokd pain, hoarseness and dysphagia.
Author: Moustafa Elnahas,Waleed/ Title: Contemporary Management of Solitary Thyroid Nodule
National Nodulf for Biotechnology InformationU. Many studies have been published in which the ability to predict whether a thyroid nodule is benign or malignant on the basis of US findings was assessed Colour Doppler US has also been evaluated as a diagnostic tool for predicting thyroid cancer, with the hypothesis that flow that is predominantly at the periphery of a nodule is suggestive of a benign nodule, while flow predominantly in the central portion of the nodule is suggestive of malignancy.
The adenomatous colloid nodules are either observed or suppressed by thyroxin, also surgery is recommended if the nodule grows; for the exclusion of malignancy. J Clin Endocrinol Metab.
In benign neoplastic nodules, most patients with a benign solitary thyroid nodule on FNAC undergo observation or levothyroxine suppression therapy.
The final histopathological diagnosis of the resected gland proved that 33 patients Total thyroidectomy was done in those cases where FNAC was reported as malignant.
Malignancy in solitary thyroid nodule: A clinicoradiopathological evaluation
Davies L, Welch HG. Predictive value of ultrasound and color-Doppler features. This high incidence of malignancy reported in our study is similar to that of Tai et al.
These markers accurately distinguish benign from malignant thyroid nodules, even in the subset of cytologically indeterminate FNABs.
F ratio of 1: In other malignant lesions, total or near total thyroidectomy is performed with adjuvant treatment according to the type of malignancy, except in lymphoma whose response to chemotherapy and external radiation give good results. Management strategy involves the integration of information theiss a variety of possible sources including history, clinical examination, biochemical assessment and a spectrum of additional investigation.
Int J res Med Sci. The methods of solitary nodule management depends chiefly on the scheme used in the diagnosis and treatment. But in cases of carcinoma completion thyroidectomy with adjuvant treatment in the form of radioactive iodine and suppressive therapy.
Before surgery, these patients were made euthyroid by supplementing thyroxin or by treatment with anti-thyroid drugs. During the study period, patients were operated for various thyroid diseases. Risk of malignancy in nonpalpable thyroid nodules: Also have increased the predictability of malignancy by FNAB for suspicious and unsatisfactory smears.
Seventeen of 58 Among endocrine diseases, thyroid nodules; both cystic and solid, have been treated effectively using this technique. Malignant thyroid nodule, solitary thyroid nodules, thyroid surgery. Two thyrold, thyroid peroxidase and galectin-3, seem to be particularly promising as practical tools to improve the accuracy of FNAB. Patients with aneuploid differentiated thyroid tumors have poorer prognosis compared with patients with diploid tumors.
Thyroid function test was done in all patients. Each patient was subjected to fine needle aspiration cytology FNAC examination, and cell block preparation. Evaluation of a thyroid nodule. If adenoma is diagnosed, only thyroxin therapy for suppression is used.