The thermodynamically stable formulations will not show any change in visual description [ 46 , 59 ]. Oils like cottonseed oil and soybean oil composed of LCTs are reported to enhance the bioavailability of highly lipophilic drugs by stimulation of lymphatic transport of drugs [ 7 , 26 ]. For the pharmacokinetic studies, 12 rats were randomly assigned to two groups. Mechanism of Self-Emulsification The free energy of the emulsion can be described by the following equation: At different compositions, different structures may be formed like emulsions, microemulsions, micelles, inverted micellar forms, and so forth and the extent of formation of these structures can be known with the construction of phase diagram.

Higher zeta potential indicates the good stability of formulation [ 54 ]. Particle size reduction may not be useful in case of all drug components because of disadvantages associated with fine powders like poor wettability and low stability [ 3 ]. Above the range, the opposite effect is observed due to the disruption of interface with the surfactant of high concentration that leads to entry of water into oil droplets [ 3 ]. Due to their high polarity, they tend to migrate towards aqueous phase upon dispersion into aqueous media leading to drug precipitation. The total analytical run time was 15 minutes. Self-microemulsifying drug delivery systems are recent and effective approach for the augmentation of oral bioavailability of many poor water soluble drugs provided that the drug should be potent with high lipid solubility.

AD-1, a novel ginsenoside derivative, shows anti-lung cancer activity via activation of p38 MAPK pathway and generation of reactive oxygen species. Lipid based delivery system like lopinavir loaded SLN was found to deliver high amount of drug in to lymphatic circulation compared to control pure drug due to which the first pass extraction of this drug was inhibited and hence bioavailability was found improved [ 10 ].

Instead, modified or hydrolyzed oils of vegetable origin are beneficial due to their superior emulsification properties and compatibility with oral administration as their end products of degradation bear a resemblance to the end products produced by digestion process in the intestine [ 22 ].


Phase separation and decrease in drug solubilization are commonly observed at higher temperature than the cloud point due to the susceptibility of surfactant to dehydration [ 42 ]. Introduction Advances in in vitro screening methods like combinatorial chemistry are leading to the emergence of many potential chemical components with marked therapeutic activity.

self microemulsifying drug delivery system thesis

Eur J Mciroemulsifying Sci. Due to their high polarity, they tend to migrate towards aqueous phase upon dispersion into aqueous media leading to drug precipitation.

If oil and aqueous phase have high diffusion coefficients and are of the same magnitude as pure components, it indicates the presence of bicontinuous type microemulsion [ 55 ]. It is determined spectrophotometrically after dilution thewis formulation with water, keeping water as blank. The resulting emulsions were observed visually for their relative turbidity.

[Full text] Self-microemulsifying drug-delivery system for improved oral bioavaila | IJN

The higher the polarity, the faster the drug release from the oil droplet into the aqueous phase. The greater bioavailability from the SMEDDS can be achieved when the dose is very low especially for the drugs with microemulsjfying octanol: Selection of the surfactant was governed by emulsification efficiency Table 3. Stability studies are performed as per the ICH guidelines on the formulation which is filled in gelatin capsules.

Mechanism of Self-Emulsification The free energy of the emulsion can be described by the following equation: Then, the samples should be subjected to centrifugation followed by filtration through 0. Published 12 February Volume We also retain data in relation to our visitors and registered users for internal purposes and for sharing information with our business partners.

International Scholarly Research Notices

Patel D, Sawant KK. Each group contained six rats. Some of the commonly used cosolvents are short chain alcohols like ethanol, n-butanol, propylene glycol, and polyethylene glycol [ 330 ].

Most of the surfactants have impact on lipid digestion that is catalyzed by lipase in various ways like the formation of complexes with the enzyme at interface, by preventing the adsorption of enzyme at interface or by the interaction with the lipase itself.


When poor solubility is the major mictoemulsifying for insufficient absorption of drug, lipid based formulations are preferred [ 29 ].

Microemulsion formed upon dilution with water produces droplets of very narrow size and size distribution for effective drug release, in vivo absorption, and also stability. The flow rate was 1. Oils are the important component of SMEDDS, as solubilization and access of the drug to the lymphatic circulation of poor water soluble drugs depend on the type and concentration of oil used for formulation.

self microemulsifying drug delivery system thesis

Among various lipid based formulations liposomes, solid lipid nanoparticles, self-dispersing tablets, and solid solutionsself-microemulsifying formulations are receiving xystem attention by formulation scientists as these are advantageous in the aspect of their stability, self-dispersing nature, ease of preparation, and scale-up. Microemulsions as carriers for drugs and nutraceuticals.

Viscosity of diluted SMEDDS formulation that is microemulsion is generally determined by rheometers like Brookfield cone and plate rheometer fitted with cone spindle [ 55 ] or rotating spindle Microemulisfying viscometer [ 56 ]. Precipitation is common if the formulation contains water soluble cosolvents and can be avoided by increasing the concentration of surfactant [ 51 ].

Cosolvents facilitate the dissolution of surfactant and hydrophobic drug in oil phase because of their ability to access the entry of water into the formulation. Based on these results, we selected Labrafil M and Labrafac Lipophile WL for the oil phase, Cremophor EL and Tween as the surfactant, and glycerin as the cosurfactant for further investigation. Pharmacokinetic parameters were mixroemulsifying using a standard noncompartmental method. International Scholarly Research Notices.

self microemulsifying drug delivery system thesis

Although many formulation approaches like solid dispersions, complexation, pH modification, and cocrystals exist, lipid based delivery systems finding increased appliance with the apparent increase in absorption of drug.