RENINOMA CASE REPORT AND LITERATURE REVIEW

Diagnostic imaging is employed to identify the source of excessive renin production. The use, distribution or reproduction in other forums is permitted, provided the original author s or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. The levels of these hormones can also fluctuate with time, but the elevation above the upper range limit is usually sustained. Cytogenetic examination of the tumor revealed normal female karyotype 46, XX without any chromosomal abnormalities. All tumor cells stained strongly for CD Hypertensive target organ damage evaluation revealed normal magnetic resonance imaging MRI of the brain and structurally normal heart. As symptoms are non-specific, there is often a delay in diagnosis of hypertension

This tumor would also likely have been missed on MRI because of its small size. Surgical resection of reninoma is curative and restores normal blood pressure in the majority of patients. As previously mentioned, kidney function was normal and there was no proteinuria or hematuria present. It is important to remember that these medications affect the production and secretion of RAAS hormones and thus alter the blood levels of these hormones. There was normal systolic function and trivial aortic regurgitation by echocardiogram, likely due to the hypertension. Metastatic juxtaglomerular cell tumor in a year-old man. J Hypertens 26 2:

The tumor cells were uniform with round nuclei and eosinophilic granular cytoplasm Figure 4 B. Comparison of 1, laparoscopic and open partial nephrectomies for single renal tumors. To preserve as much normal functional nephron mass as possible, nephron-sparing surgery in the form of partial nephrectomy, wedge excision, or even tumor enucleation are all possible alternatives to complete nephrectomy for reninomas. Similar articles Malignant hypertension due to a large reninoma: Reninomas are negative for S protein, HMB melanoma and angiomyolipoma markerschromogranin, synaptophysin neuroendocrine markersand cytokeratin a pan-epithelial marker more specific for RCC.

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Reninoma: case report and literature review. – PubMed – NCBI

There were no family members diagnosed with hypertension or cardiovascular disease. Intern Med 52 Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin. Immunoperoxidase staining for renin was not available. Juxtaglomerular cell tumor in an 8-year-old revisw.

Reninoma: case report and literature review.

Chromosome abnormalities in juxtaglomerular cell tumors. Twenty-four-hour urine collection revealed normal sodium mmol and potassium 53 mmol excretion in 1.

As previously mentioned, rpeort function was normal and there was no proteinuria or hematuria present. There is a mild female to male predominance with a ratio 1.

Renal vein renin sampling with lateralization. Hypertensive crisis in children.

Similar renionma our literatur, many of the reported cases of reninomas presented with a long-standing history of headaches with a significant delays in diagnosis of hypertension 7911 This case demonstrates the utility of both appropriate imaging studies and selective venous catheterization following provocative administration of an ACE-I for diagnosis. In this paper, we describe the case of reninoma in an adolescent girl, who presented with a long history of headaches suggestive of renin-mediated hypertension.

Potassium excretion is commonly within normal daily limits; however, this is inappropriately normal excretion, given the depletion of body potassium stores. AU – Haynes, Claudia M.

No use, distribution or reproduction is permitted which does not comply with these terms. Examination of the heart deninoma normal heart sounds and no murmurs.

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Reninoma: Case report and literature review

Ideally, the measurement of plasma and urine electrolytes is done before any treatment including intravenous fluid administration is instituted. The changing face of pediatric hypertension in literaure era of the childhood obesity epidemic.

reninoma case report and literature review

Am J Nephrol 39 1: Computed tomographic angiography CTA excluded RAS, but revealed a rounded 10 mm diameter subcapsular mass under the surface rsport the anterior midpole of the left kidney Figure 1suggestive of reninoma.

Chromosomal abnormalities have been reported in cases of reninoma, with monosomy of chromosome 9, 11, and 15, and polysomy of chromosomes 3, 4, 10 13, 17, and 18 3.

reninoma case report and literature review

ans We describe a case of reninoma and provide a review of the literature, with a discussion emphasizing the diagnostic evaluation for such patients. Pediatr Blood Cancer 50 2: Access to Document They are typically diagnosed in adolescents and young adults with occasional cases reported in younger children 6 — 9.

There was normal systolic function and trivial aortic regurgitation by echocardiogram, likely due to the hypertension. As a particularly rare litersture of hypertension, reninoma is seldom strongly considered in the imaging work-up in cases of pediatric hypertension.

Other reported symptoms are nausea, polyuria with polydipsia, and fatigue Complete resection of reninoma with an adequate rim of normal kidney tissue at least 0.