Table 1 Characteristics of patients with acute organophosphate poisoning. The agents responsible for mortality were different. Hence, heart failure occurs, and consequently the proportion of heart failure increases. Baotou Yi Xue ; Various types of OP were included in this study.

Among the 34 patients in the control group, there are 4 cases with renal failure This case is inapplicable to poisons with a high lipid solubility or binding rate with proteins. Further randomized controlled studies of the beneficial effects of hemoperfusion on patient survival are required. Lipid emulsion treatments are commonly used in resuscitating OP poisoning patients but few studies regarding their use have been reported. Observation and treatment of acute complications during the hemodialysis. It is estimated by the World Health Organization that approximately , persons die of organophosphorus pesticide poisoning per year. Find articles by Hyo-Wook Gil.

However, when considering the brain AChE the 2-PAM only induced a small reactivation of the enzyme from the second hour of the treatment administration. In acute organophosphate poisoning the efficacy of hemoperfusion on clinical status and mortality. To date, blood purification technique is used for severe and acute organophosphoruus poisoning, including continuous blood purification, hemodialysis, and hemoperfusion.

thesis on organophosphorus poisoning

In summary, this study verifies that hemoperfusion and hemodialysis on the basis of routine treatment can improve the success rate of clinical rescue, and improve the prognosis of patients, which is worthy of clinical popularization and application for treating organophosphorus pesticides poisoning patients with renal organophosphlrus.

By contrast, in our study, hemoperfusion was ineffective for improving survival, although it should be emphasized that the patients who were hemoperfused had high APACHE II scores, which makes it difficult to evaluate the effect of hemoperfusion. The detrimental effects of organophosphate OP nerve agents have been reported but poisoninb mechanisms mediating these multiple poisonijg are not well understood.


Eddlestone reported differences in the toxicity of OP [ 21 ]. The clinical parameters are summarized in Table 4.

Factors for Determining Survival in Acute Organophosphate Poisoning

The analysis demonstrates that the CPF blood concentration significantly decreased over the first 24 hours after administration. Please review our privacy policy.

Patients in the control group received routine emergency treatment, while patients in the treatment group additionally received hemoperfusion plus hemodialysis on the basis of routine emergency treatment. In Korea, the mortality due to poisoning has increased rapidly since [ 6 ]. We propose an extended model of cardiovascular regulation to assess heart rate variability in patients poisoned with organophosphate during their treatment with mechanical ventilation.

Author information Article notes Copyright and License information Disclaimer. Patients develop vascular spasm and tissue hypoxia and ischemia induced by a large amount of ACh, which result in the release of a large number of inflammatory mediators, and leads to multiple organ dysfunction syndrome and microcirculation disorder.

thesis on organophosphorus poisoning

The authors have no conflicts of interest to disclose. Pretreatment with pyridostigmine organophoephorus has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication. The agents responsible for mortality were different.

Various types of OP were included in this study. Human mortality in organophosphate poisoning. The management protocol for each OP in humans needs further study. Organophosphates account for many of the world’s deadliest poisons.


Most recent papers with the keyword organophosphate poisoning | Read by QxMD

Self poisoning with pesticides. However, there are some tthesis about hemoperfusion and hemodialysis treatment: Types of poisoning include the following: Hemodialysis technique can fully eliminate poisons with small molecular weight, low lipid solubility, and bonding rate with proteins plisoning on diffusion and ultrafiltration effects.

Human umbilical cord perivascular cells: A systematic review and meta-analysis. However, the effectiveness of oximes in humans is still doubtful, mainly due to the polarity of these compounds, which leads to poor penetration of these drugs into the central nervous system CNS.

Patients in the control group received routine emergency treatment, including gastrolavage, catharsis, rehydration, maintenance of water-electrolyte balance, thssis anti-infection treatment.

Find articles by Kwon-Hyun Lee. Initial diagnoses were established in all cases based on cholinergic clinical features, the odor of OP in the gastric contents, history, and other circumstantial evidence, such as the poison or a label of an OP-containing product found by relatives.

Information on the patients according to hemoperfusion treatment is presented in Fig. Hemoperfusion and hemodialysis on the basis of routine emergency treatment for critical patients with organoohosphorus poisoning can improve rescue outcomes and improve the prognosis of patients, which should be popularized. In a study of 52 OP-poisoned patients, Altinop et al.