A case of bupropion-induced Stevens-Johnson syndrome with acute psoriatic exacerbation. Exacerbation of psoriasis induced by interferon-alpha treatment for melanoma. Such mechanistic insights have helped to eludicate the pathophysiological pathways underlying psoriasis. New-onset psoriasis in a patient treated with interferon beta-1a. Unfortunately, despite dual therapy, her skin disease has continued to progress over her trunk and lower legs. Finally, interferon-gamma, which was studied as a potential psoriasis treatment in the early s, has been described to induce psoriasis at the injection site of interferon-gamma. Closely related to the role of interferon-alpha in psoriasis development is imiquimod.

Psoriasis induced or aggravated by drugs. Clinicians should be aware of potential associations, but currently a practice gap exists in the recognition and management of drug-related psoriasis. You can learn about our use of cookies by reading our Privacy Policy. She has not had a relapse of her psoriasis despite continuation of etanercept therapy. Summative statistics for our case series are listed in Table 2. The findings were consistent with psoriasis Figure 2 C.

palmoplantar pustular psoriasis induced by adalimumab a case report and literature review

For some medications such as lithium, beta-blockers, and imiquimod, a direct drug effect is suspected. Increased overall drug utilization in patients with psoriasis: There are no clear specific psoriasis phenotypes provoked by the different drugs implicated in drug-related psoriasis.

Her joint disease remains under good control. There have been several recent case reports on bupropion-associated psoriasis and cases of erythrodermic pustular psoriasis requiring in-hospital treatment. Am J Clin Dermatol ;9: Advanced Search Users Online: Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.


Recognizing potential drug-related psoriasis is of clinical relevance to allow an optimal management of psoriasis. Pustular psoriasis associated with hydroxychloroquine.

palmoplantar pustular psoriasis induced by adalimumab a case report and literature review

Pauluzzi P, Boccucci N. Psoriasis is a chronic condition of still uncertain cause. Treatment with interferon-beta is indicated for multiple sclerosis.

Sign in to save your search Sign in to your personal account. Immunohistochemical staining was performed using an avidin-biotin peroxidase system Vector Laboratories, Burlington, Ontario after antigen retrieval by microwave pretreatment. Increased casd awareness for medication-related causes of psoriasis induction or exacerbation should result in earlier recognition and treatment, which ultimately would lead to a better management in psoriasis treatment.

[Full text] Drug-induced psoriasis: clinical perspectives | PTT

This narrative review is based on a nonsystematic literature search in Medline and Embase databases. The following keywords were used: Alternatively, the induced psoriatic skin lesions can persist ie, drug-aggravated psoriasis. A year-old woman with rheumatoid arthritis and no personal or family history of psoriasis was treated with rofecoxib, leflunomide, and etanercept.

The cooccurence of rheumatoid arthritis and psoriasis of the skin in the same patient is rare. We also retain data in relation to our visitors and registered users for internal purposes and for sharing information with our business partners.

Palmoplantar pustular psoriasis induced by adalimumab: a case report and literature review.

In 1 patient, the cutaneous lesions resolved completely under treatment with topical corticosteroids and calcipotriol, whereas the other patient had persistent skin disease despite topical therapy.

Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: Psoriatic skin lesions induced by tumor necrosis factor antagonist therapy: One complicating factor is that the latency period between start of the medication and onset of psoriatic skin lesions can vary considerably between drugs.


palmoplantar pustular psoriasis induced by adalimumab a case report and literature review

A method for estimating the probability of adverse drug reactions. The development of psoriasis of the skin in a patient with a rheumatologic disease does not necessarily mean that a litertaure of the rheumatologic condition has been made. Pustular psoriasis induced by hydroxychloroquine: Traditionally, drugs that are strongly implicated in psoriasis include beta-blockers, lithium, synthetic antimalarial drugs, and imiquimod.

None, Conflict of Interest: Psoriasis provoked or exacerbated by medications: Wilson NJ, Evans S.

Palmoplantar pustular psoriasis induced by adalimumab: a case report and literature review.

New-onset psoriasis developed in 24 cases 10 patients had exacerbation of preexisting disease, and there were 9 patients with unknown clinical histories. Although well-conducted systematic studies on drug-related psoriasis are mostly lacking, traditionally strong associations have been documented for beta-blockers, lithium, antimalarial drugs such as hydroxy chloroquine, interferons, imiquimod, and terbinafine.

A psoriasis flare in the absence of known triggering factors such as infection and emotional stress should raise the possibility of a drug-related cause.