The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide. Individual macrophage cells differ markedly from each other, and change their functions in response to doses and combinations of agonists and time. J Immunol J Clin Invest Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators.
Bowdish , McMaster University, Canada. There is no set of genes that is co-expressed in large datasets that could be used as a signature of a macrophage activation state. Origin and development of dendritic cells. The site provides access to web-start versions of the Biolayout analysis of large macrophage datasets. The microarray platforms are now sufficiently reproducible and the processing methods standardized, that one can actually integrate datasets from independent laboratories, so it is not necessary to perform all studies in one laboratory. Gordon S, Taylor PR.
Around two-thirds of all transcription factors can be detected in primary macrophages, and they form a scale-free or small-world interaction network Classical or M1 activation mediates defense against bacterial pathogens.
Methods for analyzing deep sequencing expression data: Upper left panel shows the induction of transcription from this TSS when human monocyte-derived macrophages were treated with LPS.
J Leukoc Biol 96 2: The Cells of the Mononuclear Phagocyte System The mononuclear phagocyte system MPS nusiness is a family of professional phagocytes derived from hematopoietic progenitor cells under the influence 2013-4 specific growth factors. The same technology detects active promoters in the genomic vicinity, and one can infer the likely relationship between active promoters and enhancers that poan the same expression pattern across a large cell and tissue atlas Macrophage Activation Macrophages are abundant in every organ of the body, but each tissue macrophage population is distinct Sica A, Mantovani A.
Mol Cell The primary data summarized in this image are derived from Arner et al. The origin and kinetics of mononuclear phagocytes.
Frontiers | The Many Alternative Faces of Macrophage Activation | Immunology
Genome Res The tumor-associated macrophage has been considered the archetype bjsiness the M2 phenotype 7 Curr Top Microbiol Immunol Ronnblom L, Eloranta ML. The interferon signature in autoimmune diseases.
Macrophage activation by any agonist alters gene expression radically during the transition from one steady state to another. Mildner A, Jung S.
Macrophage activation and polarization. Positive feedback between PU.
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Allele-specific DNA methylation in mouse strains is mainly determined by cis-acting sequences. Transcriptional network dynamics in macrophage activation.
Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment. Origin and development of dendritic cells.
Differentiation and heterogeneity in the mononuclear phagocyte system. There is a separate set of interferon-inducible genes in many datasets, including tumors 74 implying that these genes are regulated independently of macrophage content.
Indeed, as discussed above, a Csf1r -EGFP transgene has been used as a marker for all tissue macrophages These high levels permit PU. Gordon S, Taylor PR. This association is more powerful when one has access to detailed time course data.
A transcriptional perspective on human macrophage biology. A gene expression atlas of the domestic pig. Analysis of large gene expression datasets from multiple cells and tissues reveals sets of genes that are co-regulated with the transcription factors that regulate them.